All hell breaks loose when it's discovered that Dr. Kurian's Z-Vaccine doesn't work at all and anyone who has been inoculated is now susceptible to Murphy's unique brand of mind manipulation. Meanwhile, Warren tries to free Vasquez after he's sentenced to death by La Reina.

The heroes seem to be nearing the end of their adventure when, in the Season 2 finale, they drive through the abandoned city of Los Angeles on their way to the mobile CDC lab, where Dr. Merch awaits their arrival. Meanwhile, the Zeros are hot on Murphy and the gang's heels.