The heroes get mixed up in corporate politics after they seek refuge in a hotel that has been taken over by a group of white-collar survivors; and when someone tries to shoot Murphy, the search for the suspect turns into a game of Clue, but with zombies.

All hell breaks loose when it's discovered that Dr. Kurian's Z-Vaccine doesn't work at all and anyone who has been inoculated is now susceptible to Murphy's unique brand of mind manipulation. Meanwhile, Warren tries to free Vasquez after he's sentenced to death by La Reina.