Arcadians mourn the loss of a beloved member of the community. The stem cells from Rachael's baby do provide the cure for the virus, but when Rachael suddenly goes missing, Bellamy and Maggie turn to an unexpected source for help. Henry learns the truth about Margaret and his family's role in the factory fire.

The return of Preacher James brings an ominous new energy to the town, especially for Bellamy who seems to have a strange and unnerving connection to him. Now a detainee at the government facility, Margaret keeps to herself but her reputation precedes her and the other returned definitely take notice. Then the unthinkable happens to Henry which shakes everybody's faith to their core.