NCIS Special Agent Tony DiNozzo assists the New Orleans team when a Navy lieutenant on liberty dies of the bubonic plague. The team races to locate all additional sailors on liberty, control a potential outbreak and determine the source of the highly infectious disease.

After a Navy SEAL is found murdered in a sorority house, the NCIS team must determine if the motive pertained to one of his classified missions or collegiate foul play. Meanwhile, Pride's daughter, Laurel, pays the NCIS office a visit.