After Pride's assistant, Ginny Young, escapes from a kidnapper, the NCIS team uncovers evidence of a suspect who is harvesting organs from multiple victims. Also, Pride turns to his friend, Commander Calvin Atkins, M.D., for medical and spiritual guidance as he struggles with the ramifications of his recent brush with death.

The NCIS team places Mateo Diaz, a high school gang member turned informant, in protective custody while they investigate the murder of his junior reserve officers' training corps instructor. Also, Pride needs his brother Jimmy Boyd's help to gain Mateo's trust.