Elizabeth goes to Myanmar to sign a Pacific Rim trade agreement which will modernize their power grid and benefit several of its trading partners, but she is met with resistance by the country's American ambassador who has immersed himself into the local culture. Also, Nadine attempts to mend her relationship with her estranged son.

While Elizabeth oversees a mission to track down the culprits behind a uranium heist in Eastern Europe, she also contends with highly sensitive issues in Saudi Arabia, including the apprehension of two American teenage girls who intended to join a terrorist group, that threatens to dismantle an important arms deal.