After an American aid worker is killed in Syria by the first known American ISIS leader, Elizabeth recalls all aid workers stationed there, including her brother, Will (Eric Stoltz), and makes it her mission to get justice for the victim. Also, Henry is conflicted when Dmitri asks for help saving Ivan (Dennis Staroselsky), who has been called back to Moscow,

As tensions rise with Russia, Elizabeth, Russell and Mike B. hatch a plan to oust Craig Sterling from his role as National Security Advisor without tarnishing President Dalton with a scandal. Also, Ephraim Ware, the Director of National Intelligence, identifies who hacked Air Force One