As the 20th anniversary of the American embassy bombing in Uganda approaches, emotions run high among the State Department staff, who had personal connections to lives lost that day, including Elizabeth, who must decide if the U.S. should lift sanctions against the country deemed responsible. Also, Henry tries to help Jason break up with Piper.

Elizabeth's negotiations for a security agreement combatting gang violence in Central America becomes complicated when she attempts to free an American recently kidnapped there.