While Elizabeth is away on a retreat thinking about her presidential campaign, her staff tries to secure an international agreement to protect citizens who have been displaced due to global warming. Also, the staff works to contain a measles outbreak that threatens the life of Daisy's daughter, Joanna.

As Elizabeth prepares to officially declare her candidacy for president, she must deal with fallout from a news article alleging she had an affair with President Dalton during her CIA days. Also, Mike B. and Jay adjust to the growing pains in their expanded roles as campaign staffers, and Elizabeth calls for a UN criminal tribunal against Myanmar military leaders over their treatment of the Rohingya.