In the aftermath of a deadly attack on the White House, Elizabeth tries to keep a major nuclear disarmament deal from falling apart while a manhunt for the attackers brings D.C. to a halt. For advice, Elizabeth turns to former secretaries of state Madeleine Albright, Hillary Clinton and Colin Powell.

Elizabeth flies to Fashion Week in Milan to face off against the Chinese Foreign Minister over an anti-sweatshop treaty in the aftermath of a tragedy. Also, Daisy struggles with feelings of fear and pessimism over her baby's future, under the threat of rising nationalism in the wake of the attack on the White House.