Annie has a bad cold, so what she really needs is rest, but what she gets is locked out of her apartment, as well as a request to check on a neighbor whose friends fear may be dead. Annie's flu forces her to try to spend a quiet day at home alone, but her apartment turns into Grand Central Terminal when each of her friends has a crisis and comes to her for advice. Annie's day is anything but restful when Elliot asks her to critique his latest short story, Roger finds a mole on his neck and thinks he is dying, and Didi has an emotional breakdown when Jim cancels a date.

When Didi's ex-husband shows up at her rent raising party, Annie, who didn't know he existed, feels betrayed by Didi and considers ending their friendship. Also at the party, Elliot, who is feeling rejected by his career-oriented wife, flirts with another woman, and Roger complains that he is being smothered by his lastest conquest, a woman he met only hours before.