Set within a dystopian future driven by a global fertility crisis, The Lottery reveals a world staring down the barrel of impending extinction as women have mysteriously stopped bearing children. After years of research, a talented young scientist, Dr. Alison Lennon, and her team remarkably fertilize 100 human eggs. However, her victory is short-lived when the government takes control of her lab and informs the President of the monumental scientific breakthrough. To determine which women will carry the prized embryos to term, Chief of Staff, Vanessa Keller, convinces the President to hold a national lottery and a battle over the control of the 100 embryos begins.

Vanessa, Darius, and President Westwood deal with the hostage crisis. Alison and James make a strange discovery after testing Kyle that may lead to more questions than answers. The world reacts to news of the lottery as the U.S. government prepares to open the testing centers.