As Jess' job search kicks into high gear, the guys fear her time of the month is also affecting their physical and psychological well-being. Meanwhile, Schmidt begins a "50 Shades of Grey"-type of relationship with his corporate boss, and Nick gains wisdom from an unlikely, hands-on source.

When Jess learns that a friend is pregnant, both she and Cece panic that time is running out for them to have children. Meanwhile, Schmidt seeks advice on how to please Emma, and Nick and Winston visit the zoo to find inspiration for Nick's zombie-themed novel.