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Sarah regresses to old habits while struggling to cope with a loss. Following in Beth's footsteps, Sarah questions her strength to carry on.
When Cosima admits doubts about finding a cure in time to save her life, Sarah makes a lone decision that exposes Kendall to those she's spent years hiding from. Meanwhile, Art and Felix team up to protect naïve clone, Krystal Goderitch, from herself.
As Alison is terrified by Neolution threats made against Donnie, Sarah and Mrs. S question her loyalty to her sestras. Siobhan sneaks out to seek vengeance. Cosima and Susan Duncan work together in a final attempt to discover a cure.
The new season sees Sarah returning home from her Icelandic hideout to track down an elusive new ally tied to deceased clone Beth, whose identity Sarah stole in the series' first episode. With the stakes higher than ever before, Sarah and her sisters band together to uncover the missing chapter of the clone conspiracy – following Beth's footsteps into a dangerous relationship with a potent enemy who holds the key to their survival.