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With Susan Duncan deposed, Sarah finds herself in the same position as Rachel–under Evie Cho's heel. The archenemies form an uneasy alliance in an attempt to bring Evie down and restore Susan to power.
As Alison is terrified by Neolution threats made against Donnie, Sarah and Mrs. S question her loyalty to her sestras. Siobhan sneaks out to seek vengeance. Cosima and Susan Duncan work together in a final attempt to discover a cure.
When communication with Cosima is cut off and Neolution appears to be within striking distance, Sarah's alliance with Rachel goes out the window. Sarah lures a high-level Neolutionist into a trap, and sets out to bring down Neolution once and for all.
The new season sees Sarah returning home from her Icelandic hideout to track down an elusive new ally tied to deceased clone Beth, whose identity Sarah stole in the series' first episode. With the stakes higher than ever before, Sarah and her sisters band together to uncover the missing chapter of the clone conspiracy – following Beth's footsteps into a dangerous relationship with a potent enemy who holds the key to their survival.