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Mrs. S. and Sarah set out to investigate a lead on a Neolution defector; an unexpected reunion takes place; Cosima has a terrible discovery.
Stuck on the sidelines with Neolutionists crawling all over her home, Alison seeks to return to her community center, but Bailey Downs has moved on from her. As she flounders to take back some semblance of control, the ghost of friendships' past rears its handsome head. Art and his new partner show up at the Hendrix residence to continue their search for Helena, forcing Art to make a difficult moral judgement.
Sarah and Kira spend time at home; secrets are unlocked about Kira's gifts; Cosima joins Delphine at the mansion.
The fifth and final season brings Sarah and the sestras to their darkest days in an effort to finally cut off the head of the snake and win their freedom. Throughout the season, the sisters individually delve into their past to confront personal struggles and emerge stronger through these self-explorations. Despite the great risk to attain freedom for themselves, their families, and the host of clone sisters they've yet to meet, clone club uncovers the missing pieces of the insidious conspiracy to finally learn the story behind their origin.