Klaus Mikaelson, the original vampire-werewolf hybrid, has returned to the supernatural melting pot that is the French Quarter of New Orleans - the city his family helped build 300 years ago. Determined to help his brother, Elijah leaves their sister Rebekah behind and follows Klaus. Elijah learns that the beautiful and rebellious werewolf Hayley - Klaus' onetime flame - has fallen into the hands of a powerful witch named Sophie Deveraux. When Sophie reveals some life-changing news, Elijah realizes that the Original family may have been given a second chance at humanity and redemption. Klaus, however, is more intrigued by his recent unexpected reunion with his former protégé, Marcel, a charismatic but diabolical vampire who now has total control over the supernatural inhabitants of New Orleans. Klaus vows to reclaim what was once his - the power, the city and his family.

After discovering interesting news about someone in Marcel's inner circle, Klaus and Rebekah come together to attempt to unravel Marcel's empire from within in spite of Elijah's concerns. They enlist help from Sophie, who is reluctant to get involved for fear of the wrath of Marcel's secret weapon, Davina. Rebekah sneakily invites an oblivious Cami to a huge vampire party thrown by Marcel, managing to anger Marcel in the process. Elsewhere, Hayley learns from the witch Sabine that the supernatural creatures of New Orleans are reacting to the potential existence of a hybrid baby.