Rebekah, who has spent months away living a normal life with baby Hope, finds herself on the run when she realizes Esther has uncovered her whereabouts. Convinced that Vincent and Kaleb would be powerful allies in his fight to take down Esther, Klaus sets a plan in motion to turn his brothers against their mother. Meanwhile, Hayley is conflicted when she and Jackson stumble upon an ancient ritual that would get their werewolf packs out from under Esther's control, but would require her to make a tremendous sacrifice. Elsewhere, Rebekah is concerned when she notices something is off with Elijah. Finally, Davina takes matters into her own hands by turning to dark magic, and Cami finds herself at the center of Esther's dangerous plan.

With Vincent on the loose and hell bent on revenge, Klaus brings Cami to the safe house as he and Hayley return to the compound. Hayley and Jackson devise a plan to bring the vampires and werewolves together to consider a truce, but tensions grow when Vincent places a spell on the compound, trapping the two sides together. Meanwhile, Elijah grows concerned when Rebekah fails to show up at the safe house, prompting Klaus to confront Kaleb for answers. Lastly, after accepting her mother's offer to jump into a new body, Rebekah turns to former Harvest girl Cassie for help when she finds herself trapped inside an insane asylum.