Booth and Brennan investigate a case of illegal organ harvesting after Brennan discovers why the daughter of FBI Deputy Director Sam Cullen is dying of a rare form of lung cancer. 

While trying to determine the identity of a Jane Doe, Brennan is shocked to learn the remains are those of her mother, who went missing with her father fifteen years ago. Brennan discovers her mother was murdered more than a year after her parent's disappearance and is determined to find out what happened.