The Jeffersonian Christmas party is interrupted when Booth arrives with the remains of a body from the 1950s recently discovered in an old fallout shelter. The team is then quarantined inside the lab after they are inadvertently exposed to Valley Fever. 

A baby is found at the scene of a dead body found inside a burned car. After the child swallows a piece of evidence, Booth and Brennan must care for the child while trying to solve the murder of his mother.