In the Season 10 premiere of BONES, Brennan and the Jeffersonian team are desperately working to get Booth out of jail, clear his name and absolve him of crimes he did not commit. The remains of a man who has been dead 16 years could be the point of origin in the entire government conspiracy that ultimately put Booth in jail. Meanwhile, Booth is faced with a challenge from a new and politically ambitious FBI agent. As he awaits trial, Booth also realizes that many of the convicts with whom he is locked up are criminals he put in there, and Daisy and Sweets have a surprise for the rest of the Jeffersonian team.

With the help of "squintern" Rodolfo Fuentes, the Jeffersonian team investigates the murder of a controversial conservative radio host whose remains were found in a storm drain. When the team discovers some of his extracurricular activities, they come across shocking evidence that narrows down the suspects. Meanwhile, Special Agent James Aubrey is desperate to gain the trust of Booth, and Brennan is worried about Booth's psychological well-being after recent events.