When remains of real estate agent Justin Ross are found in the forest and appear to have been destroyed by coyote-wolf hybrids, Brennan enlists the help of fellow brilliant forensic anthropologist Dr. Beth Mayer (guest star Betty White) to assist in the investigation. In addition to her professional achievements, Mayer is surprisingly knowledgeable about the world of fantasy football, a key link to Ross' past and one that could provide vital information in finding his killer. As Booth and Aubrey dig into Ross' fantasy football league history, they discover he was actively involved in a Twitter feud with NFL star Lou Divers (guest star Ronde Barber), and was also owed a large sum of money from the league's commissioner, making each of them suspects. Meanwhile, Brennan resists feeling competitive as Mayer impresses the team with her expertise and decades of accomplishments.

A pair of funny sanitation workers discover the shredded body of a U.S. Senator in a street sweeper, which leads Brennan, Booth and the team to Capitol Hill, where they meet with U.S. Senator and majority whip Hayley Winters and the victim's chief of staff Eric Morales to get to the bottom of this political murder. Meanwhile, as Aubrey starts to develop a relationship with squintern Laura, he looks into her past to make sure nothing will harm his dream of a future in politics.