The Jeffersonian team investigates the death of Jared Drew, an animal expo employee, and in the course of their investigation into his death, they enter the world of illegal animal trafficking. Meanwhile, Brennan thinks she would make an excellent presidential candidate, and Sweets and Daisy take on a big change in their relationship.

When Brennan becomes fascinated with basketball and the underlying concepts behind Phil Jackson's philosophy of "teamwork," she calls upon five of her best "squinterns" to complete the task of identifying remains that have been deemed unidentifiable. During their investigation, the squints uncover the identity of a man who died as a result of the 9/11 terrorist attacks, which propels the team to determine if he was a perpetrator or a victim.