The Jeffersonian team investigates the death an art school dropout struggling with Lupus, whose remains were found inside a log in a forest. When the team learns about the victim's use of cannabis to treat her pain, it leads them to the dispensary where she worked, and they uncover more shocking details that could have contributed to her death. Meanwhile, squintern Wendell Bray returns after starting cancer treatments, and while working on the case, he starts to open up more about his illness, only to reveal some shocking news that may end in his termination. Also, Booth preps for his FBI Competency tests.

The Jeffersonian team investigates the death of Stephanie McNamara, the daughter of a wealthy family whose remains were found in a national park. When the team digs deeper into the circumstances surrounding her death, clues from the case lead them to believe she may be the Ghost Killer's latest victim, with a surprising connection to a previous victim. Meanwhile, the FBI Deputy Director takes a special interest in the team's high-profile case and Booth's career may be in for some changes.