The Jeffersonian team investigates the murder of Charlie McCord, a high school principal who, upon learning he had terminal cancer, created a website where people could go and pay for his inspirational videos. When the team finds a suspicious video of Charlie punching former UFC Light Heavyweight Champion Chuck Liddell in the face, it leads the team to Charlie's bucket list, which ultimately helps them get closer to solving the case. Meanwhile, Brennan and Booth finally start to plan their wedding and Sweets could be replaced by a virtual profiling system.

While honeymooning in Buenos Aires, Brennan and Booth can't just relax on vacation. So, instead, they decide to help Raphael Valenza, a local detective and huge fan of Brennan's books, solve the murder of a Nazi war criminal whose remains were found in an historic mass grave. Meanwhile, back in Washington, D.C., Hodgins and Angela struggle to take care of Christine while Brennan and Booth are away.