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Penny's ex-boyfriend, Zack, and his wife want a baby, but when Zack is infertile, they ask Leonard for help. Also, Koothrappali attempts to mend things with his ex-fiancée, Anu.
Penny and Leonard organize a paintball game that results in mayhem when Sheldon is jealous of Amy. Also, Koothrappali catches Anu with her ex-boyfriend, and Stuart doesn't want to move in with Denise.
When Sheldon and Amy's super asymmetry theory is proven by two physicists, Dr. Pemberton and Dr. Campbell from Chicago, they're thrilled, until they try to kick Amy off the Nobel nomination. Also, Bernadette has a big success at work and Penny's going to be a part of it – whether she wants to or not.