Gunshots, a fleeing van and a massive blood pool all point to murder, but when Castle & Beckett arrive at the crime scene, they discover that it lacks something - the victim! The investigation leads to the cutting-edge world of life-extension science, a cunning high-tech researcher (guest star William Atherton), and a sleazy porn mogul who invested in a modern-day "fountain of youth." Meanwhile, Alexis finds out whether she got into Stanford.

Castle & Beckett work a murder case around the theft of a valuable sculpture. Kristin Lehman guest stars as Serena Kaye, a smart, sexy insurance investigator, who joins Castle & Beckett in the investigation, but she also has her eyes set on Castle, all the while hiding a very important secret from the team. Jessica Tuck also guest stars as Joy McHugh, a wealthy museum benefactor who becomes a suspect in the murder investigation.