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An act of terror strikes Cheyenne as Cullen, Durant and Campbell negotiate toward a settlement for policing the streets.
Cullen goes head-to-head with the new marshal in an attempt to free his arrested railroad workers. Meanwhile, Campbell confronts Louise over a story.
Cullen and Durant fight to save the life of a criminal. Meanwhile, Louise tries to provide support as Ruth copes with a great loss.
Conflict arises between the government and businesses, ranchers, homesteaders and the railroad, as all of those interests compete with one another for control of Cheyenne, Wyoming, the most important railroad hub in 1867. Meanwhile, the Union Pacific Railroad continues its expansion westward, and Bohannon adjusts to being a husband and new father.