As Hotch fights for his life due to complications from his stabbing at the hands of George Foyet, a.k.a. "The Reaper," he experiences visions of his late wife, Haley, and his nemesis, Foyet. Meanwhile, the BAU searches for a missing teenager and investigate her estranged father as a suspect in her disappearance.

After a series of strangulations in Boston, the BAU looks for an UnSub who likes to keep mementos of the victims, and the team wonders if a common link to the casualties could lead them to the culprit. Meanwhile, the BAU rallies around Rossi when his favorite bar is on the verge of closing.