The show that inspired the nation to get healthy is back with 50 contestants, one from each state in the country. New surprises await the contestants including the addition of fitness veteran, Kim Lyons as the new red team trainer. The contestants will quickly learn that only 14 of them will stay and train at the ranch while 36 will go home to compete on their own with a chance to make it back to the ranch and win $250,000. In the first challenge, the teams will square off in a wall scaling competition for the power to switch one team member's weight-loss with someone on the opposing team.

This week the teams must battle the buffets while going on a luxury cruise vacation. Bob and Kim show the teams how to make healthy food choices and work exercise into a vacation. During the challenge contestants will deliver room service orders all over the ship for the chance to win time with their loved ones. Each week the teams find out how much weight they have lost during the weigh-in and the losing team must send one of their own home from the ranch.