In the Season 2 premiere, an unexpected attack on Gabriel's Aerie puts a newly freed Alex and Noma on the road to New Delphi, a dangerous and mysterious city. Meanwhile, Claire begins to understand the breadth of her responsibility; and Michael stumbles upon a quaint southern town whose residents have inexplicably managed to insulate themselves from the fallout of the Extermination War.

Alex embarks on a dangerous quest to prove himself to his new ally, during which a startling face from his past appears; at the same time, Claire enlists the help of an old friend to halt what she believes is a brewing revolt from the V1s; and Michael makes a sacrifice that will prevent him from ever being with his love.