A man about to go on trial for arson and the murder of his wife and child seeks assistance from Grissom to help prove his innocence. Meanwhile, Catherine and Nick investigate the underground world of sports gambling when a teenager is murdered at close range.

When a single human bone is discovered in the desert, Grissom and Catherine must cover miles of territory to find the rest of the skeleton. And Warrick and Sara trace the death of a male stripper to members of a wedding party who may have celebrated a little too hard the night before the nuptials.