Grissom and his team investigate the death of a first class passenger on a flight to Las Vegas. The investigators are forced not only to examine the physical evidence, but also to interview all of the first class passengers to get their personal accounts of the incident.

A woman is abducted from a supermarket. In the store, Grissom finds a bathroom stall door that claims five women have been killed. Warrick is caught in a casino on duty and is paired with a reluctant Sara. Their case is the apparent murder and robbery of a man who is found by his brother. Nick gets pulled in by his prostitute friend who gets in a scuffle with hotel security.