Catherine and Detective Vartann are thrown together in a hotel room for 24 hours as they stake out a duo making drugs in the room next door. Meanwhile, Nick and Langston work a case that involves a fetish which has become big business in Vegas.

When Hodges and Wendy take a group of high school CSI Explorer Scouts on a field trip, they embellish their role in solving cases and take their assignment a little bit too far.