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When the CSI team investigates the brutal murder of a family, they trace the killer to the house next door, which might belong to the "Dr. Jekyll" serial killer.
Catherine and Detective Vartann are thrown together in a hotel room for 24 hours as they stake out a duo making drugs in the room next door. Meanwhile, Nick and Langston work a case that involves a fetish which has become big business in Vegas.
When Hodges and Wendy take a group of high school CSI Explorer Scouts on a field trip, they embellish their role in solving cases and take their assignment a little bit too far.