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The CSIs investigate the demise of a famous Cuban singer's sister who's in town as part of a U.S. tour. Meanwhile, Hodges begins to get cold feet at the prospect of marrying his Italian bombshell girlfriend.
When CSI Mac Taylor decides to surprise his girlfriend in Vegas, he discovers she's missing and asks his friend D.B. Russell for help. Meanwhile, the CSIs investigate the loss of a local wine collector on part one of a two-part crossover with CSI:NY.
Sara is a lead suspect in an investigation after a brief encounter with another man in which she was the last person to see him alive. Also, her separation from Grissom begins to take a toll.