After 15 seasons and more than 300 episodes, the CSI team of D.B. Russell, Sara Sidle, Greg Sanders, Dr. Albert Robbins, David Phillips, David Hodges, Morgan Brody and Henry Andrews welcome back Gil Grissom, Catherine Willows and Jim Brass for their final case, when they investigate a catastrophic event that paralyzes all of Las Vegas. Russell and Sidle will make decisions regarding their crime-fighting careers, and the return of Lady Heather will create controversy one last time between Grissom and Sidle.