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Grissom and Catherine investigate the stabbing death of an 80-year-old woman who lived in a run-down house full of cats; Nick and Sara comb through the remains of a car bombing that was, apparently, a murder plot gone awry.
Jane Galloway is a nervous breakdown waiting to happen. She has completely shielded herself from the outside world, but that doesn't stop a stalker in her attic from killing her. When CSI arrives, they find her hair dyed and her face shoved in the toilet. This image has a heavy impact on Nick, and they soon realize that this stalker is well acquainted with Nick, which makes the CSI the next target.
Grissom and Sara investigate when a man's body, which has been doused with lye, is found buried in a park; Nick tries to determine how a hiker apparently drowned in a desert.