Grissom and crew are called in after high roller Tony Braun, a known drug addict, is found dead in his house by a gardener. Since drug paraphernalia are discovered near his body and it is also determined that he had recently inhaled heroin, the cause of death is at first thought to be an overdose. But further examination of the corpse reveals that Braun had been restrained at some point with duct tape, leading Grissom to believe that the victim was forced to ingest lethal amounts of heroin and, perhaps, other drugs.

Grissom investigates a possible suicide at a high-profile construction site. Against the wishes of the Sheriff, Grissom pushes to get at the truth of the matter-he thinks the suicide was actually a homicide, and uses theories on electrocution to look for his killer. Meanwhile, Nick and Catherine take on a case with little more than angora fibers to follow. A teenage boy dies while in session with his female psychologist, and traces of angora on his underwear make them believe the psychologist may be practicing very unconventional methods of "therapy."