The CSI team is called in when a famous real estate entrepreneur is found dead in a hotel elevator. When the body of Bob Fairmont, the real estate developer, is found, the team discovers that the crime scene has been tampered with and that the victim has been re-dressed. After tracing the cause of death to a lethal poison, the team is shocked to discover that Fairmont's organs have already been removed and donated, making the case a bit more difficult to solve.

Grissom's nemesis, serial killer Paul Millander (Matt O'Toole), reappears and claims a third victim in this gripping episode. The latest slaying matches Millander's previous killings in that it recreates his father's murder, which Millander witnessed as a boy. In each case, the victim is shot once through the chest while lying in a bathtub. A nearby tape recorder contains the person's supposed suicide message. All three victims share the same birthday of Aug. 17---the date Millander's father was slain---with the years in descending order from 1959. So presumably, the killer's next target was born Aug. 17, 1956...which just happens to be Grissom's birthday.