Grissom and Catherine investigate the murder of a despised comic who died onstage, apparently after drinking from a tainted bottle of water. The case grows more puzzling when a 15-year-old boy dies in a convenience store after drinking the same brand of water. Brass reopens a woman's accidental-death case after spotting the deceased's husband in a flashy new car with a trophy date on his arm.

Grissom, Sara, and Nick investigate the murder of a woman in the press box of a high school stadium. They arrive less than an hour after the woman's death. Catherine and Warrick try to determine the cause of an explosion in the DNA lab of CSI that seriously injures a lab tech. The personal lives of our characters come into play in this episode.