Warrick investigates the drive by murder of a young girl in his old neighborhood. The girl's father is a friend and mentor of Warrick's as well. Warrick struggles to control his emotions to the point where Grissom pulls him off of the case. Nick tackles the murder of a computer company employee. The only supects are the three other employees in the building.

Warrick and Grissom investigate the death of a man found at a foam party. Nick works on the case of a man found dead in his home. Catherine and Grissom investigate the death of a women who was involved with the aforementioned two men, all of which lead to Lady Heather. Catherine desperately tries to find out where her missing daughter and ex-husband are. Sara eventually takes over the case.