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Warrick's addiction to pills begins to impact his job when his investigation into the underground mob in Vegas results in him being targeted as the prime suspect in a mob-related murder case.
Hodges has ulterior motives when he stages hypothetical murders in the lab to give his colleagues a chance to play CSI. Also, everyone tries to reach out to Grissom after Sara's departure.
Grissom and his team delve into the world of illegal dog fighting to find out who is responsible for the death of a wealthy socialite. Meanwhile, Warrick tries to clear his name in the murder of an exotic dancer.