When a teenage lacrosse player is stricken with an unidentifiable brain disease, Dr. House and the team hustle to give his parents answers. Chase breaks the bad news that the kid has multiple sclerosis, but the boy's night-terror hallucinations disprove the diagnosis and send House and his team back to square one. As the boy's health deteriorates, House's side-bet on the paternity of the patient infuriates Dr. Cuddy and the teenager's parents but may just pay off in spades.
 

Dr. House exasperates his boss, Dr. Lisa Cuddy, when he suggests that two sick newborn babies in one hospital add up to an epidemic from a spreading virus. Even more frightening is that he may be right as four more babies fall ill, the maternity ward closes, and the doctors battle over courses of treatment. House and his team must make decisions that could compromise the babies' lives.