When Death Row inmate Clarence mysteriously and suddenly collapses after hallucinating, House jumps at the chance to take the case for its difficulty and because it's "cool" over Cuddy and Foreman's objections. Dr. Cameron refuses to treat the patient in protest and feels they should treat a cancer patient because she's more deserving, raising the question: is one life more important than another? Also, House must now work closely with Stacy.

When Cuddy's handyman Alfredo, a young Latino and the sole provider for his family, falls from her roof and develops strange darkened pinkies, Cuddy joins the team in trying to figure out what's wrong with him.