House and his team take on a new patient, Bob, who comes to Princeton Plainsboro Teaching Hospital after suffering from a breathing attack while role-playing in the bedroom with his wife. The symptoms point to heavy metal poisoning, but the tests do not. House believes a woman is trying to kill her husband and tries to find the proof to confirm his suspicions. When Wilson moves in with House after separating from his wife, he learns Wilson is a great cook.

It's poker night at Princeton Plainsboro when the hospital hosts an oncology benefit. A 6-year-old boy is brought in exhibiting symptoms that aren't too unusual; however, when House learns of additional specifics, he jumps on the case right away.