A graduating Princeton student suffers a seizure from internal shocks while partying at a frat house and is rushed to Princeton Plainsboro Hospital. With his father Ken at his bedside, it becomes apparent the two haven't been truthful about their lives with each other. Their trust issues prevent the medical team from getting the necessary information to diagnose and treat Carnell's illness. Also, House's parents drop by to see their son.

Kalvin, a gay man with full-blown AIDS, confronts House in front of his home, demands that House figure out what's causing his illness - besides HIV or AIDS - and collapses at his feet, going into shock. When House discovers the man's father is suffering from symptoms of his own, he must determine any connection to save both their lives. Meanwhile, Cameron faces a potentially life-threatening disease of her own.