House takes on the case of 20-year-old female patient Tracy Dawson, who is rushed to Princeton Plainsboro Teaching Hospital with breathing difficulties and unexplained intense abdominal pain after she and her husband, Jeremy, are victims of a robbery. Meanwhile, House and clinic patient Michael Tritter have a touchy altercation, leaving Tritter appalled and furious at the way House treated him.

Kyle comes to the hospital regularly to visit his father, Gabe, who has been in a coma for 10 years. Noticing something "off" about Kyle, House conducts a mini-experiment that leaves the boy unconscious. When symptoms point to a possible genetic condition, House and his team must glean a family history from Kyle's only living relative - his comatose father.