Addie, a 19-year-old college student, is admitted to Princeton Plainsboro after coughing up a mouthful of blood during karate class. Before treating the patient, Foreman unapologetically informs the rest of the team that he is resigning, but will not say why.

Cuban couple Esteban and his sick wife, Marina Hernandez, are pulled from the ocean during a dangerous rescue en route to the U.S. on a mission to reach Dr. House. Her detailed medical records from Cuba were lost during the rescue, so the team runs a series of tests to determine the extent of her heart condition. But when she gets worse, House wonders if someone on his staff made a mistake. Meanwhile, Foreman prepares to leave, and his departure shakes up the entire team with House firing Chase and Cameron resigning.