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When a 20-year-old funeral home cosmetician, Irene, has a massive seizure, she hallucinates the cadavers in the funeral home have come to life, House and the remaining seven fellowship candidates must figure out why.
The final 10 fellowship candidates compete ferociously when House splits them into two teams by gender. They are assigned to diagnose and treat a wheelchair-bound man with muscular atrophy who is slowly suffocating.
The team takes on the case of a man who collapsed while being mugged. When the man complains of new symptoms that do not fit his initial admission profile, the team suspects he is a hypochondriac. As Mr. X continues to fall ill with symptoms unrelated to his neurological disorder, Foreman and the remaining six fellows are assigned to keep watch, and are bemused as they see their own behavioral idiosyncrasies reflected through him.
After losing his original diagnostic team, House decides that he doesn't need fellows as he feels that he can handle a case all on his own but after taking a long time to solve a case, Cuddy insists that he start looking for possible doctors to join his new team. House grudgingly accepts and gets forty applicants together and has a reality show style contest to see which lucky three applicants will stay on to get the vacant fellowship openings. Meanwhile, Cameron and Chase come back to work at the hospital, while Foreman starts work in a job similar to House's at another hospital. However, Foreman is soon fired for doing exactly what House would do and winds up back at Princeton-Plainsboro. House wants nothing to do with him, but Cuddy insists he can only hire two new fellows and must have Foreman on his team to keep an eye on him.