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House is convinced one of the actors on his favorite soap opera "Prescription Passion" has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands.
House suspects an emergency room patient has a bigger problem then the ER initially diagnosed based on the fact that the patient is too nice. A skeptical House questions the patient's sunny disposition as the team tries to get to the bottom of his illness. Meanwhile, House and Amber are at odds about how much time they each get to spend with Wilson, and Cuddy demands House give his team performance reviews.
House finds himself dazed, confused and covered in blood after surviving a bus accident that left dozens seriously injured. Unable to clearly recall the events leading up to the crash due to his head injuries, House becomes convinced through his flashbacks that a fellow bus passenger was exhibiting signs of a deadly illness prior to the crash.
After losing his original diagnostic team, House decides that he doesn't need fellows as he feels that he can handle a case all on his own but after taking a long time to solve a case, Cuddy insists that he start looking for possible doctors to join his new team. House grudgingly accepts and gets forty applicants together and has a reality show style contest to see which lucky three applicants will stay on to get the vacant fellowship openings. Meanwhile, Cameron and Chase come back to work at the hospital, while Foreman starts work in a job similar to House's at another hospital. However, Foreman is soon fired for doing exactly what House would do and winds up back at Princeton-Plainsboro. House wants nothing to do with him, but Cuddy insists he can only hire two new fellows and must have Foreman on his team to keep an eye on him.